neurotensin receptor 3 (sortilin, SORT1)
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Function
- sorting receptor in the Golgi
- clearance receptor on the cell surface
- protein transport from the Golgi apparatus to lysosomes (M6PR-independent)
- protein transport from Golgi to endosomes
- promotes neuronal apoptosis by mediating endocytosis of proapoptotic precursor forms of BDNF (proBDNF) & NGFB (proNGFB)
- receptor for neurotensin
- scavenges extracellular LPL
- mineralization of extracellular matrix during osteogenic differentiation - induced during osteoblast differentiation
- formation of specialized storage vesicles containing glucose transporter SLC2A4/GLUT4 in adipocytes
- transport from endoplasmic reticulum to Golgi (putative)
- interacts with LPL, SLC2A4, GGA1, GGA2, LRPAP1/RAP, GM2A, PSAP
- forms complex with NGFR which binds to precursor forms of NGFB (proNGFB) & BDNF (proBDNF)
Structure
- N-terminal propeptide may facilitate precursor transport within Golgi
- N-terminal propeptide is cleaved by furin
- intrachain binding of the N-terminal propeptide & extracellular domain may inhibit premature ligand binding
- extracellular domain may be shed following protease cleavage
- contains 9 BNR repeats
Compartment
- membrane, endoplasmic reticulum, endosomes, Golgi stack, lysosomes, nucleus, plasma membrane (small fraction), SLC2A4/GLUT4 storage vesicles in adipocytes
- localization to plasma membrane in adipocytes may be enhanced by insulin
Expression
- expressed in brain, spinal cord, heart, skeletal muscle, thyroid, placenta, testis > lymphoid organs, kidney, colon, liver