hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL, hairy-related transcription factor 3, hHRT3, HEYL HRT3)

Function

• downstream effector of Notch signaling
• may be required for cardiovascular development
• transcriptional repressor
• binds preferentially to canonical E box sequence 5'-CACGTG-3'
• represses transcription by cardiac transcriptional activators GATA4 & GATA6
• self-associates
• interacts with GATA4, GATA6, HES1, HEY1 & HEY2
• interacts with HDAC1, NCOR1 & SIN3A

Structure

• belongs to the HEY family
• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 Orange domain

Compartment

nucleus

Expression

• induced by activation of Notch signaling pathway

More general terms

• hairy & enhancer of split (HES)
• transcriptional silencer (transcriptional repressor)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NQ87.html