recombining binding protein suppressor of hairless; J kappa-recombination signal-binding protein; RBP-J kappa; RBP-J; RBP-JK; CBF-1; renal carcinoma antigen NY-REN-30 (RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH)

Function

• transcriptional regulator
• role in notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations
• acts as a transcriptional repressor when it is not associated with notch proteins
• when associated with some notch protein, it acts as a transcriptional activator that activates transcription of notch target genes
• probably represses or activates transcription via recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively
• specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence
• interacts with activated NOTCH1, NOTCH2 or NOTCH3
• interacts with MINT/SHARP; this interaction may mediate recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 & CIR1
• interacts with EP300, MAML1 & PTF1A
• interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 & EBNA6

Structure

• belongs to the Su(H) family
• contains 1 IPT/TIG domain

Compartment

nucleus

Alternative splicing

named isoforms=6; APCR-1, APCR-2, APCR-3

Notes

• despite some similarity with the phage integrase family, it has no recombinase activity

More general terms

• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q06330.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3516
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3516
• OMIM: https://mirror.omim.org/entry/147183