mastermind homolog MAML1 (Mastermind-like protein 1, KIAA0200)

Function

• transcriptional coactivator for NOTCH proteins
• amplifies NOTCH-induced transcription of HES1
• enhances phosphorylation & proteolytic turnover of NOTCH intracellular domain in the nucleus via interaction with CDK8
• induces phosphorylation & localization of CREBBP to nuclear foci
• binds to ankyrin repeat domain of all 4 Notch receptors
• forms DNA-binding complex with Notch proteins & RBPSUH
• binds CREBBP, CDK8

Compartment

• nucleus, nucleoplasm, nuclear speckle

Expression

• widely expressed
• highest levels in heart, pancreas, peripheral blood leukocytes, spleen

More general terms

• mastermind-like family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9794
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9794
• OMIM: https://mirror.omim.org/entry/605424
• UniProt: http://www.uniprot.org/uniprot/Q92585.html