cyclin-dependent kinase-8 (CDK8, protein kinase K35, mediator complex subunit CDK8)

Function

• component of the mediator complex
• recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation
• interacts with CTNNB1, GLI3 & MAML1

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

More general terms

• cyclin-dependent kinase (CDK)

Component of

• CDK8/cyclin C complex
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• UniProt: http://www.uniprot.org/uniprot/P49336.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1024
• OMIM: https://mirror.omim.org/entry/603184
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1024