docking protein 2; downstream of tyrosine kinase 2; p56(dok-2) (DOK2)

Introduction

Docking proteins interact with receptor tyrosine kinases & mediate particular biological responses. Fuctions:

• may modulate cellular proliferation induced by IL-2, IL-3 & IL-4
• role in modulating Bcr-Abl signaling
• attenuates EGF-stimulated MAP kinase activation (putative)
• phosphorylated on C-terminal Tyr after receptor tyrosine kinase stimulation
• phosphorylation on Tyr-345 required for binding to the SH2 domain of NCK
• phosphorylation on both Tyr-271 & Tyr-299 is required for interaction with RasGAP
• phosphorylated on Tyr by TEK/TIE2 (putative)
• interacts with phosphorylated RASGAP & EGFR
• interacts with RET & NCK
• interacts (via PH domain) with TEK/TIE2 (Tyr phosphorylated)

Structure

• PTB domain mediates receptor interaction
• belongs to the DOK family, type A subfamily
• contains 1 IRS-type PTB domain
• contains 1 PH domain

Expression

• highly expressed in peripheral blood leukocytes, lymph nodes & spleen

More general terms

• docking protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9046
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9046
• OMIM: https://mirror.omim.org/entry/604997
• UniProt: http://www.uniprot.org/uniprot/O60496.html