interleukin-22 [IL-22] receptor alpha 1 (IL-22R-alpha-1, cytokine receptor family 2 member 9, CRF2-9, IL22RA1, IL22R)
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Function
- component of the receptor for IL20, IL22 & IL24
- component of IL22 receptor formed by IL22RA1 & IL10RB enabling IL22 signaling via JAK/STAT pathways
- IL22 also induces activation of MAPK1/MAPK3 & Akt kinases pathways
- component of receptor for IL20 & IL24 formed by IL22RA1 & IL20RB also signaling through STATs activation
- mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation & differentiation
- heterodimer with IL10RB & with IL20RB
- IL22 binding to heterodimer is greater than binding to IL22RA1 alone
Structure
- belongs to the type II cytokine receptor family
- contains 2 fibronectin F3 modules
Compartment
membrane
Expression
- expressed in colon, liver, lung, pancreas & kidney
- no expression in immune cells such as monocytes, T-cells, & NK-cells
- expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions
- induced by interferon-gamma in keratinocytes
Pathology
- strongly expressed on central nervous system vessels within inflitrated multiple sclerosis lesions
- overexpressed in synovial fluid cells from rheumatoid arthritis & spondyloarthropathy patients
- failure of medical & surgical therapy in chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1