interleukin-22 receptor alpha-2; IL-22R-alpha-2; interleukin-22-binding protein; IL22BP; cytokine receptor family class II member 10; CRF2-10; cytokine receptor family type 2, soluble 1; CRF2-S1 (IL22RA2)

Function

• isoform 2 is a receptor for IL-22
• binds to IL-22
• prevents interaction with the functional IL-22R complex
• blocks activity of IL-22
• IL-22 antagonist in the regulation of inflammatory responses (putative)
• isoform 1 may play a role in establishing & maintaining successful pregnancy

Structure

belongs to the type II cytokine receptor family

Compartment

secreted

Alternative splicing

named isoforms=3

Expression

• expressed in placenta, spleen, breast, skin, lung, intestinal tract, testis, brain, heart, thymus
• soform 1 is expressed only in placenta
• isoform 2 is expressed in placenta, breast > spleen, skin, thymus, stomach

More general terms

• secreted protein

Additional terms

• interleukin-22 [IL-22] receptor alpha 1 (IL-22R-alpha-1, cytokine receptor family 2 member 9, CRF2-9, IL22RA1, IL22R)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1163
• OMIM: https://mirror.omim.org/entry/606648
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=116379
• UniProt: http://www.uniprot.org/uniprot/Q969J5.html