interleukin-24; IL-24; melanoma differentiation-associated gene 7 protein; MDA-7; suppression of tumorigenicity 16 protein (IL24, MDA7, ST16)

Function

• antiproliferative in human melanoma cells
• terminal cell differentiation (putative)
• negative regulator of melanoma progression (putative)
• induces apoptosis in human breast cancer cells

Structure

belongs to the IL-10 family

Compartment

secreted

Alternative splicing

named isoforms=3

Pathology

• up-regulated in melonoma cells induced to terminally differentiate

More general terms

• interleukin
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11009
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11009
• OMIM: https://mirror.omim.org/entry/604136
• UniProt: http://www.uniprot.org/uniprot/Q13007.html