interleukin-10 receptor beta chain; IL-10R-B; IL-10R2; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; CRF2-4; CDw210b (IL10RB, CRFB4, D21S58, D21S66)
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Function
- accessory subunit for receptors for IL10 & IL22
- serves as an accessory chain essential for the active IL10 receptor complex & to initiate IL10-induced signal transduction events
Structure
- belongs to the type II cytokine receptor family
- contains 2 fibronectin F3 modules
Compartment
membrane
Pathology
- defects in IL10RB are associated with susceptibility to hepatitis B
- defects in IL10RB found in infantile-onset Crohn's disease
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q08334.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il10rb
- ↑ Glocker E-O et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009 Nov 19; 361:2033 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19890111
Kelsall B. Interleukin-10 in inflammatory bowel disease. N Engl J Med 2009 Nov 19; 361:2091. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19890110