DnaJ homolog subfamily B member 11; APOBEC1-binding protein 2; ABBP-2; DnaJ protein homolog 9; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; ER-associated dnaJ protein 3; ERdj3; ERj3p; HEDJ; Human DnaJ protein 9; hDj-9; PWP1-interacting protein 4 (DNAJB11, EDJ, ERJ3, HDJ9, PSEC0121, UNQ537/PRO1080)

Function

• co-chaperone for HSPA5
• binds directly to both unfolded proteins that are substrates for ERAD & nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed
• may help recruiting HSPA5 & other chaperones to the substrate
• stimulates HSPA5 ATPase activity
• Thr-188 was reported to be phosphorylated upon DNA damage by ATM or ATR; however as this position is in the ER lumen, & the in vivo relevance is unknown
• part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 & very small amounts of ERP29, but not, or at very low levels, CALR nor CANX
• binds to denatured substrates (ATP-independent)
• interacts via the J domain with HSPA5 (ATP-dependent)

Structure

• contains high-mannose endo H-sensitive carbohydrates
• Cys-169, Cys-171, Cys-193 & Cys-196 form intramolecular disulfide bonds
• the preferential partner for each Cys is not known
• contains 1 J domain

Compartment

• endoplasmic reticulum lumen
• associated with the ER membrane in a C-terminally epitope-tagged construct

Expression

• widely expressed
• induced by ER stress-inducing agents such as thapsigargin & tunicamycin

More general terms

• DNAJ homolog subfamily B
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51726
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51726
• OMIM: https://mirror.omim.org/entry/611341
• UniProt: http://www.uniprot.org/uniprot/Q9UBS4.html