endoplasmin; heat shock protein 90 kD beta member 1; 94 kD glucose-regulated protein; GRP94; gp96 homolog; tumor rejection antigen 1 (HSP90B1, TRA1)

Function

• molecular chaperone
• functions in the processing & transport of secreted proteins
• has ATPase activity
• phosphorylated (putative)

Structure

• homodimer; disulfide-linked
• component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 & HSPA5 (putative)
• part of a large chaperone multiprotein complex consisting of: CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 & very small amounts of ERP29, but not, or at very low levels, CALR nor CANX
• belongs to the heat shock protein 90 family

Compartment

• endoplasmic reticulum lumen. melanosome
• identified by mass spectrometry in melanosome fractions from stage 1 to stage 4

Comparative biology

• alias hsp108 (in chicken); 94 kD glucose-regulated protein (GRP94) (in hamster)

More general terms

• heat shock protein [hsp]-90 family
• chaperonin; chaperone

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7184
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7184
• OMIM: https://mirror.omim.org/entry/191175
• UniProt: http://www.uniprot.org/uniprot/P14625.html