protein disulfide-isomerase A4; protein ERp-72; ERp72 (PDIA4, ERP70, ERP72)

Function

• catalyzes the rearrangement of -S-S- bonds in proteins
• part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 & very small amounts of ERP29, but not, or at very low levels, CALR nor CANX

Structure

• belongs to the protein disulfide isomerase family
• contains 3 thioredoxin domains

Compartment

• endoplasmic reticulum lumen
• melanosome, stages 1-4

Notes

originally thought to be a deoxycytidine kinase

More general terms

• protein disulfide isomerase

Database

• UniProt: http://www.uniprot.org/uniprot/P13667.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9601
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9601