calreticulin; CRP55; calregulin; HACBP; ERp60; grp60 (CALR, CRTC)
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Function
- molecular Ca+2 binding chaperone promoting folding, oligomeric assembly & quality control in the ER via the calreticulin/calnexin cycle
- this lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER
- interacts with the DNA-binding domain of NR3C1 & mediates its nuclear export monomer
- component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 & HSPA5
- interacts with PDIA3/ERp57 & with NR3C1 (putative)
Structure
- can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure & a C-terminal acidic domain
- the P-domain binds one molecule of Ca+2 with high affinity; the acidic C-domain binds multiple Ca+2 with low affinity
- the interaction with glycans occurs through a binding site in the globular lectin domain
- the Zn+2 binding sites are localized to the N-domain
- associates with PDIA3 through the tip of the extended arm formed by the P-domain
- belongs to the calreticulin family
- molecular weight by mass spec: mass=46879[8]
Compartment
- endoplasmic reticulum lumen, cytoplasm, secreted
- extracellular space, extracellular matrix
- cell surface
- found on cell surface (T cells), cytosol & extracellular matrix
- associated with the lytic granules in cytolytic T-cells
Pathology
- CALR gene mutation may be associated with
Notes
- originally thought to be the 52 kD Ro autoantigen[7]
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P27797.html
- ↑ Wikipedia; Note: calreticulin entry http://en.wikipedia.org/wiki/calreticulin
- ↑ Functional glycomics gateway - glycan binding Note: calreticulin http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_other_405
- ↑ Burns K et al Modulation of gene expression by calreticulin binding to glucocorticoid receptor. Nature 367:476 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107808
- ↑ Dedhar et al Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367:480 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107809
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=811
- ↑ 7.0 7.1 McCauliffe DP Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. J Clin Invest. 1990 May;85(5):1379-91 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2332496
- ↑ 8.0 8.1 Holaska JM et al Calreticulin Is a receptor for nuclear export. J Cell Biol. 2001 Jan 8;152(1):127-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149926