calreticulin; CRP55; calregulin; HACBP; ERp60; grp60 (CALR, CRTC)

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Function

Structure

  • can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure & a C-terminal acidic domain
  • the P-domain binds one molecule of Ca+2 with high affinity; the acidic C-domain binds multiple Ca+2 with low affinity
  • the interaction with glycans occurs through a binding site in the globular lectin domain
  • the Zn+2 binding sites are localized to the N-domain
  • associates with PDIA3 through the tip of the extended arm formed by the P-domain
  • belongs to the calreticulin family
  • molecular weight by mass spec: mass=46879[8]

Compartment

Pathology

Notes

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/P27797.html
  2. Wikipedia; Note: calreticulin entry http://en.wikipedia.org/wiki/calreticulin
  3. Functional glycomics gateway - glycan binding Note: calreticulin http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_other_405
  4. Burns K et al Modulation of gene expression by calreticulin binding to glucocorticoid receptor. Nature 367:476 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107808
  5. Dedhar et al Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367:480 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107809
  6. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=811
  7. 7.0 7.1 McCauliffe DP Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. J Clin Invest. 1990 May;85(5):1379-91 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2332496
  8. 8.0 8.1 Holaska JM et al Calreticulin Is a receptor for nuclear export. J Cell Biol. 2001 Jan 8;152(1):127-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149926

Database