calreticulin-3 (calreticulin-2, CALR3, CRT2)

Function

• molecular Ca+2 binding chaperone
• promotes folding, oligomeric assembly & quality control in the endoplasmic reticulum via calreticulin/calnexin cycle
• may interact transiently with almost all monoglucosylated glycoproteins synthesized in the ER

Structure

• lectin
• belongs to the calreticulin family
• domains
  • N-terminal globular domain
    • interaction with glycans occurs through a binding site in the globular lectin domain
    • Zn+2 binding sites are localized to the N-domain
  • proline-rich P-domain forming an elongated arm-like structure - binds one Ca+2 with high affinity
  • C-terminal acidic domain
    • binds multiple Ca+2 with low affinity

Compartment

endoplasmic reticulum lumen

Expression

testis specific

More general terms

• Ca+2 binding protein
• lectin
• testis-specific protein

Additional terms

• calreticulin; CRP55; calregulin; HACBP; ERp60; grp60 (CALR, CRTC)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96L12.html