cyclophilin B (peptidyl-prolyl cis-trans isomerase B, S-cyclophilin, CypB, PPIB, SCYLP, CYP-S)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
• cyclosporin A binds to & inhibits cyclophilin B

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIase B subfamily
• contains 1 PPIase cyclophilin-type domain

Compartment

• endoplasmic reticulum lumen, melanosome

Notes

• identified by mass spectrometry in melanosome fractions from stage I to stage IV

More general terms

• cyclophilin
• chaperonin; chaperone

Database

• UniProt: http://www.uniprot.org/uniprot/P23284.html
• OMIM: https://mirror.omim.org/entry/123841
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5479