thapsigargin

Introduction

Tumor promoter

Mechanism of action

• inhibits endoplasmic reticulum Ca+2 ATPase
• discharges intracellular Ca+2 stores
• induces unfolded protein response

More general terms

• cycloheptane
• ester
• alcohol
• alkene; olefin
• enzyme inhibitor

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5321923
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=446378
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=49926
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5428