meningiococcemia (purpura fulminans)

From Aaushi
Jump to navigation Jump to search

Introduction

Purpura fulminans refers to the skin hemorrhage resulting from disseminated intravascular coagulation associated with meningococcemia. Less frequently, DIC associated with malignancy or massive trauma may produce purpura fulminans.

Etiology

Epidemiology

  • meningococcemia occurs primarily in children & young adults
  • higher rates in winter & spring
  • epidemic outbreaks in crowded living conditions

Clinical manifestations

* images[5][6]

Complications

Management

More general terms

More specific terms

Additional terms

References

  1. H. Quinny Cheng, USSF Fresno lecture, Oct 21, 1998
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 95
  3. 3.0 3.1 3.2 Thompson MJ, Ninis N, Perera R, Mayon-White R, Phillips C, Bailey L, Harnden A, Mant D, Levin M. Clinical recognition of meningococcal disease in children and adolescents. Lancet. 2006 Feb 4;367(9508):397-403. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16458763
  4. 4.0 4.1 Thompson MJ et al, Clinical recognition of meningococcal disease in children and adolescents. Lancet 2006, 367:397 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16458763
  5. 5.0 5.1 Kugai T, Nakagawa H. (images) Evolution of Purpura Fulminans. N Engl J Med 2017; 376:2182. June 1, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28564574 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1700231
  6. 6.0 6.1 6.2 Elkston CA, Elkston DM Bacterial Skin Infections: More Than Skin Deep. Medscape. July 19, 2021 https://reference.medscape.com/slideshow/infect-skin-6003449