PRKCH upstream open reading frame 2; uORF2; protein uPEP2 (PRKCH)

Function

• product of an upstream open reading frame (ORF) of PRKCH which regulates translation of the downstream protein kinase C eta (PKC-eta) ORF
• functions as a repressive element that maintains low basal levels of PKC-eta in growing cells but enhances its expression during stress conditions
• induced by amino acid starvation in a EIF2AK4/GCN2-dependent manner
• in addition to its role in regulating PKC-eta translation, also inhibits the kinase activity of PKC-eta as well as other protein kinases including PRKCD, PRKCQ & PRKCE but not PRKCA, PRKCG or PRKCZ
• interacts with protein kinase C eta as well as other protein kinases including PRKCD, PRKCQ & PRKCE but not with PRKCG or PRKCZ
• interactions lead to inhibition of kinase activity

Notes

• suppresses proliferation & migration of cancer cells

More general terms

• protein kinase C-eta (PRKCH, PKCL, PRKCL)

Database

• UniProt: http://www.uniprot.org/uniprot/C0HM02.html