protein kinase C-gamma (PKC-I, PRKCG, PRKCC)

Function

• Ca+2-activated, phospholipid-dependent
• serine/threonine kinase
• activated by diacylglycerol
• phosphorylates a range of cellular proteins
• interacts with CDCP1

Cofactor:

• binds 3 Ca+2 per subunit
• Ca+2 are bound to the C2 domain (putative)

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 C2 domain
• contains 2 phorbol-ester/DAG-type Zn+2 fingers
• contains 1 protein kinase domain

Pathology

• defects associated with spinocerebellar ataxia type 14 (may be due to mutation rather than CAG repeat expansion)

Laboratory

• PRKCG gene CAG repeats*

More general terms

• protein kinase C type-A

Database

• UniProt: http://www.uniprot.org/uniprot/P05129.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5582
• OMIM: https://mirror.omim.org/entry/176980
• OMIM: https://mirror.omim.org/entry/605361
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5582