protein kinase C-eta (PRKCH, PKCL, PRKCL)

Function

• Ca+2-independent, phospholipid-dependent
• serine/threonine kinase
• activated by diacylglycerol
• 3 specific sites
  • Thr-512 (activation loop of the kinase domain)
  • Thr-655 (turn motif)
  • Ser-674 (hydrophobic region) need to be phosphorylated for its full activation

Structure

• C1 domain, containing the phorbol ester/DAG-type region 1 is the diacylglycerol sensor
• C2 domain is a non-Ca+2 binding domain
• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 C2 domain
• contains 2 phorbol-ester/DAG-type Zn+2 fingers
• contains 1 protein kinase domain

Expression

most abundant in lung, less in heart & skin

Pathology

• defects in PRKCH may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain & resulting in loss of motor, sensory &/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic & environmental risk factors

More general terms

• protein kinase C type-B

More specific terms

• PRKCH upstream open reading frame 2; uORF2; protein uPEP2 (PRKCH)

Database

• UniProt: http://www.uniprot.org/uniprot/P24723.html
• OMIM: https://mirror.omim.org/entry/601367
• OMIM: https://mirror.omim.org/entry/605437
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5583