eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein (EIF2AK4, GCN2, KIAA1338)

Function

• phosphorylates alpha subunit of EIF2
• translational control
• autophosphorylated on threonine residues (putative)

Structure

• RWD domain is reported to interact with GCN1L1
• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
• contains 2 protein kinase domains
  • kinase domain 1 is a degenerate kinase domain
• contains 1 RWD domain

Alternative splicing

named isoforms=3

Expression

widely expressed

Pathology

• EIF2AK4 variants are associated with:
  • pulmonary capillary hemangiomatosis
  • pulmonary veno-occlusive disease

More general terms

• serine/threonine kinase
• initiation factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=440275
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:440275
• OMIM: https://mirror.omim.org/entry/609280
• UniProt: http://www.uniprot.org/uniprot/Q9P2K8.html