hydrocodone/phenylpropanolamine (Hycomine, Codamine)

Indications

symptomatic relief of cough & nasal congestion

Contraindications

• concurrent administration of MAO inhibitor
• hypertension
• hyperthyroidism
• increased intracranial pressure
• depressed ventilation

Dosage

• adults & children > 12 years of age:
  • 5-10 mL (5-10 mg hydrocodone) every 4-6 hours PRN
  • maximum: 6 doses/24 hours
• children 6-12 years of age:
  • 2.5 mL (2.5 mg hydrocodone) every 4-6 hours PRN
  • maximum: 6 doses/24 hours

Syrup: hydrocodone bitartrate 5 mg & phenylpropanolamine HCl 25 mg/5 mL (120 mL)

Adverse effects

• common (> 10%)
  • lightheadedness, dizziness, sedation, drowsiness, weakness, tiredness, hypotension
• less common (1-10%)
  • shortness of breath, troubled breathing, confusion, diminished urination, nausea/vomiting, bradycardia, tachycardia
• uncommon (< 1%)
  • hallucinations, hypertension, double vision, dry mouth, anorexia, miosis, biliary or urinary spasm, histamine release, hot & dry skin, impaired GI motility, mydriasis, blurred vision
• other
  • rash
  • blood dyscrasias
  • nephrotoxicity with chronic use
  • hepatotoxicity
  • respiratory depression is dose & tolerance-related
  • tolerance & dependence
  • constipation

• drug adverse effects of antitussive agent(s)

Drug interactions

• naloxone is a direct opiate antagonist
• CNS depressants
• phenothiazines
• tricyclic antidepressants (TCA)

More general terms

• pharmacologic combination
• antitussive agent

Components

• hydrocodone; dihydrocodeinone (Zohydro ER, Hysingla ER)
• phenylpropanolamine (PPA)