bacitracin (AK-tracin)

Introduction

Ophthalmic: Tradename: AK-tracin

Indications

• treatment of superficial bacterial skin infections
• treatment of eye infections
  • conjunctivitis, keratitis, blepharitis, meibomitis, dacryocystitis, corneal ulcers

Dosage

Topical:

Ointment: apply 1-5 times daily. Ointment. 30 g.

Ophthalmic:

• ointment every 3-4 hours or BID-QID for 7-10 days
• apply light pressure on conjunctival sac for 1 minute after instillation
• may cause blurred vision

Antimicrobial activity

• Streptococcus
• Staphylococcus
• Anaerobic cocci
• Corynebacterium
• Clostridium
• Neisseria gonorrhoeae
• Neisseria meningitidis
• Fusobacterium
• Actinomyces israelii
• Treponema pallidum
• Treponema vincenti

Adverse effects

• topical
  • rash, allergic contact dermatitis
  • itching
• ophthalmic
  • blurred vision
  • not common (1-10%)
    • sweating, hypotension, rash, itching, anorexia, nausea/vomiting, diarrhea, blood dyscrasias, chest tightness, swelling of face & lips, rectal itching & burning, pain

Mechanism of action

• inhibits bacterial cell wall synthesis

More general terms

• other antibiotic

More specific terms

• Bacitracin Ophthalmic

Component of

• bacitracin/lidocaine
• bacitracin/colistin/cortisol
• bacitracin/lidocaine/neomycin/polymixin b
• bacitracin/lidocaine/neomycin
• bacitracin/dimethicone/zinc oxide
• bacitracin/neomycin
• bacitracin/neomycin/polymixin b/pramoxine
• bacitracin/cortisol/neomycin/polymixin b
• bacitracin/neomycin/polymixin-B (Neosporin)
• gramicidin/neomycin/polymixin-B (Opthneosporin, AK-spore)
• bacitracin/polymixin-B (Polysporin, Ocumycin)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=62281
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=457812
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=439542
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5311014
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2283
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5351545
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3082210