Fusobacterium

^[1]^[2]

Pathology

abundance in GI tract increased in patients with colorectal cancer (odds ratio 4.11)^[1]
found in 50% of colorectal cancers^[2]
fusobacterial DNA found primarily within malignant cells^[2]
fusobacterial DNA also found colorectal cancer metastases^[2]

↑ ^1.0 ^1.1 Ahn J, Sinha R, Pei Z et al Human Gut Microbiome and Risk of Colorectal Cancer. J Natl Cancer Inst (2013) Dec 6 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24316595 <Internet> http://jnci.oxfordjournals.org/content/early/2013/11/27/jnci.djt300.abstract
Mai V and Morris JG Need for Prospective Cohort Studies to Establish Human Gut Microbiome Contributions to Disease Risk. Natl Cancer Inst (2013) Dec 6 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24316594 <Internet> http://jnci.oxfordjournals.org/content/early/2013/11/27/jnci.djt349.full
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Bullman S, Pedamallu CS, Sicinska E et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 2017 Dec 15; 358:1443 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29170280 <Internet> http://science.sciencemag.org/content/358/6369/1443