Fusobacterium nucleatum
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Epidemiology
- present in the human oral cavity
- rarely found in the lower gastrointestinal tract of healthy individual[3]
Pathology
- may play a role in colorectal carcinoma
- enriched in human colorectal cancer tumors[3]
- stimulates growth of colorectal carcinoma cells
- high tumor Fusobacterium nucleatum loads are associated with recurrence, metastases & poor prognosis[3]
- tumor isolated strains are from the clade Fusobacterium nucleatum animalis C2
- Fusobacterium nucleatum animalis C2 contains a unique adhesion antigen (FadA) on its surface that binds to cell surface E-cadherin, activating beta-catenin signaling & stimulating both inflammation & carcinogenesis
- FadA gene levels in the colon tissue from patients with colorectal adenomas & colorectal adenocarcinomas are > 10-100 times higher than in controls
Management
- an 11 amino acid inhibitory peptide abolishes FadA-E-cadherin binding & both inflammatory & carcinogenic properties[1]
More general terms
Additional terms
References
- ↑ Jump up to: 1.0 1.1 Rubinstein MR et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 2013 Aug 14; 14:195. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954158
Kostic AD et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013 Aug 14; 14:207. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954159 - ↑ Kostic AD et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb;22(2):292-8. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22009990 <Internet> http://genome.cshlp.org/content/early/2011/10/04/gr.126573.111
Castellarin M et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012 Feb;22(2):299-306 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22009989 <Internet> http://genome.cshlp.org/content/early/2011/10/05/gr.126516.111
Rubinstein MR et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 2013 Aug 14; 14:195. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954158
Kostic AD et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013 Aug 14; 14:207. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954159 - ↑ Jump up to: 3.0 3.1 3.2 3.3 Zepeda-Rivera M, Minot SS, Bouzek H et al. A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche. Nature 2024 Apr 11; 628:424 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38509359 PMCID: PMC11006615 Free PMC article. https://www.nature.com/articles/s41586-024-07182-w