Fusobacterium nucleatum

^[1]^[2]

Pathology

may play a role in colorectal carcinoma
stimulates growth of colorectal carcinoma cells
contains a unique adhesion antigen (FadA) on its surface that binds to cell surface E-cadhern, activating beta-catenin signaling & stimulating both inflammation & carcinogenesis
FadA gene levels in the colon tissue from patients with colorectal adenomas & colorectal adenocarcinomas are > 10-100 times higher than in controls

an 11 amino acid inhibitory peptide abolishes FadA-E-cadherin binding & both inflammatory & carcinogenic properties^[1]

↑ ^1.0 ^1.1 Rubinstein MR et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 2013 Aug 14; 14:195. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954158
Kostic AD et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013 Aug 14; 14:207. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954159
↑ Kostic AD et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb;22(2):292-8. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22009990 <Internet> http://genome.cshlp.org/content/early/2011/10/04/gr.126573.111
Castellarin M et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012 Feb;22(2):299-306 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22009989 <Internet> http://genome.cshlp.org/content/early/2011/10/05/gr.126516.111
Rubinstein MR et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 2013 Aug 14; 14:195. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954158
Kostic AD et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013 Aug 14; 14:207. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23954159