pentosan polysulfate (Elmiron, PPS, polypentose sulfate)

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Introduction

Tradename: Elmiron.

Indications

Dosage

  • 100 mg PO TID
  • take with water 1 hour prior to meals or 2 hours after meals
  • re-evaluate therapy in 3 months
  • discontinue if no improvement in 6 months

Capsule: 100 mg.

Pharmacokinetics

  • 3 to 6 months of therapy may be required before benefits are observed

elimination via kidney

Adverse effects

Drug interactions

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Nickel JC et al. Pentosan polysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome: Insights from a randomized, double-blind, placebo controlled study. J Urol 2015 Mar; 193:857 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25245489 <Internet> http://www.jurology.com/article/S0022-5347%2814%2904431-0/abstract

Database