Hodgkin's disease, nodular sclerosing type

Introduction

Clinical features:

• Most common in adolescents and young adults.
• Mediastinum commonly involved.
• Stage and bulk have prognostic importance, often curable.

Pathology

• nodular or partially nodular pattern with fibrous bands. necrosis common.
• lymphocytes, histiocytes, plasma cells, eosinophils & neutrophils present.
• characteristic cell is lacunar type Reed-Sternberg cell
• diagnostic Reed-Sternberg cells usually present.

Immunophenotype

tumor cells

• CD15 +/-
• CD30 +
• CD45 -
• B-cell and T-cell antigens usually -
• EMA -

Genetics

• Ig & TCR genes usually germline
• EBV +, 40%
• bcl-2 rearrangements in some cases

More general terms

• Hodgkin's disease (Hodgkin's lymphoma)