ETS homologous factor (hEHF, ETS domain-containing transcription factor, epithelium-specific Ets transcription factor 3, ESE-3, EHF, ESE3, ESE3B, ESEJ)
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Function
- transcriptional activator
- role in regulating epithelial cell differentiation & proliferation (putative)
- repressor for a specific subset of ETS/AP-1-responsive genes
- modulcates nuclear response to mitogen-activated protein kinase signaling cascades
- binds to DNA sequences containing the consensus nucleotide core sequence GGAA
- role in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter
- role in development & carcinogenesis by acting as a tumor suppressor gene or anti-oncogene
Structure
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
- contains 1 PNT domain (pointed domain) PNT domain acts as a transcriptional activator
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed exclusively in tissues with epithelial cells
- expressed in salivary gland, mammary gland, prostate, lung > kidney, colon
- not expressed in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes
- induced by interleukin-1 beta & TNF-alpha in bronchial smooth muscle cells & fibroblasts
- induced by interleukin-10 & IFN-gamma in monocyte-derived dendritic cells