activity-dependent neuroprotector homeobox protein; activity-dependent neuroprotective protein (ADNP, ADNP1, KIAA0784)

Function

• putative transcription factor
• may mediate some of the neuroprotective peptide VIP-associated effects involving normal growth & cancer proliferation
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 9 C2H2-type Zn+2 fingers
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• widely expressed
• strong expression in heart, skeletal muscle, kidney & placenta
• expressed in cerebellum & cerebral cortex
• not expressed in the colon
• strong increase of expression in colon carcinoma & breast cancer tissues

Notes

• when isolated from the sequence, neuroprotective peptide provides neuroprotection against the beta-amyloid peptide

More general terms

• transcription factor (TF)
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23394
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23394
• OMIM: https://mirror.omim.org/entry/611386
• UniProt: http://www.uniprot.org/uniprot/Q9H2P0.html