MED8 mediator complex (mediator of RNA polymerase 2 transcription)

Function

• can either repress or activate transcription
• essential for basal & regulated expression of nearly all RNA polymerase 2-dependent genes
• may act as a bridge, conveying regulatory information from enhancers & other control elements to the promoter

Subunits

• MED12/TRAP230, PPARBP/TRAP220, CRSP6/TRAP80, CDK8, CCNC, MED6, CRSP9/MED7, CRSP8/TRAP37, USP47/TRFP, NUT2/MED10, SOH1, THRAP6/TRAP25, MED21, MED28 & THRAP4/MED24

More general terms

• mediator complex (mediator of RNA polymerase 2 transcription)