mediator of RNA polymerase 2 transcription subunit 28; endothelial-derived protein 1; mediator complex subunit 28; Merlin & Grb2-interacting cytoskeletal protein; Magicin; tumor angiogenesis marker EG-1 (MED28, EG1, FKSG20)

Function

• component of mediator complexes
  • MED8 mediator complex
  • IXL mediator complex
• may be part of a complex containing NF2/Merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways
• forms a ternary complex with NF2/Merlin & GRB2
• binds to actin

Structure

belongs to the mediator complex subunit 28 family

Compartment

• nucleus, cytoplasm
• membrane, peripheral membrane
• cytoplasmic & mainly membrane-associated (some uncertainty)

Expression

• widely expressed
• highly expressed in vascular tissues such as placenta, testis & liver
• up-regulated by endothelial cells when exposed to tumor conditional media

More general terms

• nuclear protein
• membrane protein

Component of

• MED8 mediator complex (mediator of RNA polymerase 2 transcription)
• IXL mediator complex (mediator of RNA polymerase 2 transcription)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H204.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80306