mediator of RNA polymerase II transcription subunit 24; activator-recruited cofactor 100 kD component; ARC100; cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; mediator complex subunit 24; thyroid hormone receptor-associated protein 4; thyroid hormone receptor-associated protein complex 100 kD component; trap100; hTRAP100; vitamin D3 receptor-interacting protein complex 100 kD component; DRIP100 (MED24, ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• interacts with AR

Structure

• belongs to the mediator complex subunit 24 family

Compartment

nucleus (probable)

Expression

• ubiquitous
• abundant in skeletal muscle, heart & placenta

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• thyroid hormone receptor associated protein complex (TRAP)
• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9862
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9862
• OMIM: https://mirror.omim.org/entry/607000
• UniProt: http://www.uniprot.org/uniprot/O75448.html