mediator of RNA polymerase II transcription subunit 6; activator-recruited cofactor 33 kD component; ARC33; mediator complex subunit 6; hmed6; renal carcinoma antigen NY-REN-28 (MED6, ARC33)

Function

• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• interacts with CTNNB1 & GLI3

Structure

• belongs to the mediator complex subunit 6 family

Compartment

nucleus

More general terms

• transcription factor (TF)

Component of

• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10001
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10001
• OMIM: https://mirror.omim.org/entry/602984
• UniProt: http://www.uniprot.org/uniprot/O75586.html