centaurin-delta-3; Arf-GAP with Rho-GAP domain, ANK repeat & PH domain-containing protein 3; Cnt-d3 (ARAP3 CENTD3)

Function

• PI(3,4,5)P3-dependent GTPase
• modulates actin cytoskeleton remodeling by regulating ARF & RHO family members
• activated by PI(3,4,5)P3 binding
• acts on ARF6, RAC1, RHOA & CDC42
• internalization of anthrax toxin
• Tyr phosphorylated at a low basal level
• PDGF treatment stimulates phosphorylation

Structure

• contains 1 Arf-GAP domain
• contains 3 PH domains
• contains 1 Ras-associating domain
• contains 1 Rho-GAP domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

• cytoplasm, cell membrane
• associated with F-actin-rich membrane ruffles & lamellipodia

More general terms

• centaurin delta
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64411
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64411
• OMIM: https://mirror.omim.org/entry/606647
• UniProt: http://www.uniprot.org/uniprot/Q8WWN8.html