kelch-like protein 20; kelch-like ECT2-interacting protein; kelch-like protein X (KLHL20, KLEIP)

Function

• substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response
• also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases
• protein modification; protein ubiquitination
• interacts with DAPK1
• interacts with F-actin
• interacts with IFN-gamma (IFNG)

Structure

• contains 1 BACK (BTB/kelch associated) domain
• contains 1 BTB/POZ domain
• contains 6 kelch repeats

Compartment

• cytoplasm, perinuclear region, nucleus
• localizes in the perinuclear region in normal conditions
• following IFN-alpha or IFN-gamma treatment, it is relocalized & sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination

More general terms

• kelch-like protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27252
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27252
• UniProt: http://www.uniprot.org/uniprot/Q9Y2M5.html