PDZ & LIM domain protein 7 (LIM mineralization protein, LMP, protein enigma, PDLIM7,ENIGMA)
Jump to navigation
Jump to search
Function
- scaffold on which the coordinated assembly of proteins can occur
- role as adapter, localizes LIM-binding proteins to actin filaments of both skeletal muscle & nonmuscle tissues (via its PDZ domain)
- role in bone formation
- embryonic flat bones, mandible & cranium
- endochondral bone formation, embryonic long bones
- role in bone fracture repair
- role in BMP6 signaling pathway
- binds via its LIM zinc-binding 3 domain (LIM 3) to endocytic codes of INSR, but not those of IGF1R, LDLR, TFRC, or EGFR
- interacts with various PKC isoforms through the LIM zinc- binding domains
- binds to RET via its LIM zinc-binding domain 2 (LIM 2) (phosphorylation-independent)
- component of a complex with SHC & the RET dimer
- interacts with TPM2, TBX4, TBX5
- anchored to cell periphery via its N-terminal PDZ domain
Structure
- contains 3 LIM zinc-binding domains
- contains 1 PDZ domain (DHR domain)
Compartment
- cytoplasm, cytoskeleton
- colocalizes with RET to cell periphery & in some cytoskeletal components
- colocalizes with TPM2 near the Z line in muscle
- co-localizes with TBX4 & TBX5 to actin filaments
Alternative splicing
named isoforms=6
Expression
- isoforms 1 & 2 are e ubiquitous
- isoform 2 predominates in skeletal muscle,
- isoform 1 is more abundant in lung, spleen, leukocytes, fetal liver