tropomyosin-beta; tropomyosin-2; beta-tropomyosin (TPM2, TMSB)
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Function
- binds to actin filaments in muscle & non-muscle cells
- role, in association with troponin complex, in Ca+2 dependent regulation of vertebrate striated muscle contraction
- smooth muscle contraction is regulated by interaction with caldesmon
- in non-muscle cells, implicated in stabilizing cytoskeleton actin filaments
Structure
- heterodimer of an alpha & a beta chain
- the molecule is in a coiled coil structure that is formed by 2 polypeptide chains
- prominent 7-residue periodicity
- belongs to the tropomyosin family
Compartment
Alternative splicing
named isoforms=3
Expression
- skeletal muscle
- absent from normal breast tissue
Pathology
- present in primary breast cancer tissue; absent from normal breast tissue
- defects in TPM2 are the cause of
- nemaline myopathy type 4
- arthrogryposis multiplex congenita, distal, type 1
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P07951.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPM2
- ↑ OMIM https://mirror.omim.org/entry/190990
- ↑ Harris RA Cluster analysis of an extensive human breast cancer cell line protein expression map database. Proteomics. 2002 Feb;2(2):212-23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11840567
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7169
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7169
- OMIM: https://mirror.omim.org/entry/108120
- OMIM: https://mirror.omim.org/entry/190990
- OMIM: https://mirror.omim.org/entry/609285
- OMIM: https://mirror.omim.org/entry/191010
- UniProt: http://www.uniprot.org/uniprot/P07951.html