receptor-interacting serine/threonine protein kinase 4; ankyrin repeat domain-containing protein 3; PKC-delta-interacting protein kinase (RIPK4, ANKRD3, DIK)

Function

• plays a role in NF-kappa B activation
• may be phosphorylated by MAP3K2 & MAP3K3 (putative)
• proteolytically cleaved by during Fas-induced apoptosis
• cleavage at Asp-388 & Asp-426
• interacts with PRKCB (putative)
• interacts with TRAF1, TRAF2, TRAF3 & TRAF5 ,

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
• contains 10 ANK repeats
• contains 1 protein kinase domain

Compartment

• cytoplasm, membrane

Alternative splicing

named isoforms=2

More general terms

• receptor-interacting serine/threonine protein kinase (RIPK)
• ankyrin repeat domain protein (ANKRD)

Database

• OMIM: https://mirror.omim.org/entry/605706
• UniProt: http://www.uniprot.org/uniprot/P57078.html