acidic leucine-rich nuclear phosphoprotein 32 member E; LANP-like protein (ANP32E, LANP-L)

Function

• histone chaperone
  • specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome
  • removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer & insulator regions
  • not involved in deposition of H2A.Z/H2AFZ in the nucleosome
  • may stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus driving dissociation & the off-chromatin state
• inhibits activity of protein phosphatase 2A
• does not inhibit protein phosphatase 1
• cerebellar development (putative)
• phosphorylated
  • phosphorylation is nuclear localization signal (NLS- dependent) (putative)
• interacts with the importin alpha KPNA1 & KPNA2
• component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 & ANP32E
  • the complex does not contain SRCAP

Structure

• the H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ
• belongs to the ANP32 family,
• contains 4 LRR repeats (leucine-rich repeats)
• contains 1 LRRCT domain

Compartment

• cytoplasm, nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver, kidney

More general terms

• acidic leucine-rich nuclear phosphoprotein 32 (ANP32)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81611
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81611
• OMIM: https://mirror.omim.org/entry/609611
• UniProt: http://www.uniprot.org/uniprot/Q9BTT0.html