inhibitor of growth protein 3 (p47ING3 protein, HSPC301, ING3)

Function

• component of the NuA4 histone acetyltransferase (HAT complex)
• HTATTIP/TIP60, EPC1, & ING3 together constitute a minimal HAT complex termed Piccolo NuA4

Structure

• belongs to the ING family
• contains 1 PHD-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis & thymus

Pathology

• defects in ING3 may be a cause of head & neck cancer (squamous cell carcinomas of the head & neck

Notes

• may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• protein subunit
• zinc finger protein

Component of

• NuA4 histone acetyltransferase (HAT) complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5455
• OMIM: https://mirror.omim.org/entry/607493
• OMIM: https://mirror.omim.org/entry/275355
• UniProt: http://www.uniprot.org/uniprot/Q9NXR8.html