lipase in serum
Jump to navigation
Jump to search
Reference interval
- serum: 16-196 U/L, Veterans Administration: 7-58 U/L
Principle
- see lipase in serum/peritoneal fluid
Clinical significance
- lipase is a digestive enzyme mainly produced by acinar cells of the exocrine pancreas
- its physiological role is to hydrolyze the long-chain triglycerides in the small intestine
- serum lipase increases rapidly in patients with acute & recurrent pancreatitis, pancreatic abscess or pseudocyst, pancreatic trauma, pancreatic cancer, common bile duct obstruction, & ingestion of drugs that are toxic to the pancreas
- it is also increased by most inflammatory conditions in the abdominal cavity, biliary tract diseases, abdominal abscesses, & renal failure
- lipase is somewhat more specific than total amylase in the diagnosis of acute pancreatitis
- the combined use of serum lipase & serum amylase can effectively rule out acute pancreatitis (if both are normal)
Increases
- pancreatitis
- serum lipase tends to become elevated at the same time, if not earlier, than serum amylase in patients with acute pancreatitis
- it remains elevated for about 7-10 days, rarely > 14 days
- a prolonged increase of serum lipase suggests a poor prognosis or the presence of a pancreatic cyst
- high levels of serum lipase suggest pancreatitis
- procedure-related pancreatitis after double balloon enteroscopy[8]
- intestinal ischemia
- intestinal obstruction, intestinal perforation
- duodenal ulcer
- ketoacidosis, diabetic ketoacidosis
- celiac disease
- macrolipasemia
- head trauma, intracranial mass
- renal failure[5]
- pharmaceutical agents:
- in vivo effects
- chemical interferences
Specimen
Patient Preparation: No special patient preparation is necessary. Sample Preparation: Heparin may be used as an anticoagulant for plasma specimens. EDTA, oxalate/fluoride & citrate should not be used as anticoagulants. Collect the specimens by standard venipuncture technique. Remove serum promptly from the clot & analyze as soon as possible. Ensure equipment is free from soap or glycerol contamination. Collection tubes with glycerol lubricated stoppers should not be used. Refrigerate specimens if it cannot be analyzed immediately. Freeze specimen for long-term storage or shipment.
Sample requirements:
More general terms
Additional terms
Component of
References
- ↑ Kodak Ektachem 700 Test Methodologies Manual, Kodak Clinical Products, Rochester, N.Y., 1990.
- ↑ Kodak Ektachem 700 Operators Manual, Kodak Clinical Products, Rochester, N.Y., 1987.
- ↑ Package Insert, Kodak Ektachem Special Calibrators, Kodak Clinical Products, Rochester, N.Y., 1985.
- ↑ Package Insert, Bio-Rad Liquichek Controls, Bio-Rad ECS Division, Anaheim, CA., 1992.
- ↑ 5.0 5.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, American College of Physicians, Philadelphia 1998, 2009
- ↑ Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 11.
- ↑ Lipase, Serum or Plasma Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0020014.jsp
- ↑ 8.0 8.1 NEJM Knowledge+ Gastroenterology