E3 SUMO-protein ligase PIAS3; protein inhibitor of activated STAT protein 3 (PIAS3)

Function

• E3-type small ubiquitin-like modifier (SUMO) ligase
• stabilizes interaction between UBE2I & substrate
• SUMO-tethering factor
• role in transcriptional coregulation in cellular pathways
  • STAT pathway
  • steroid hormone signaling pathway
• effects of transcriptional coregulation, transactivation or silencing may depend upon context
• sumoylated (putative)
• binds SUMO1 & UBE2I
• interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, in addition to STAT3, after treatment with IL6, CNTF or OSM interacts with STAT5 after PRL stimulation
• interacts with PLAG1
• interacts with ZFHX3

Structure

• the LXXLL motif is a transcriptional coregulator signature
• belongs to the PIAS family
• contains 1 PINIT domain
• contains 1 SAP domain
• contains 1 SP-RING-type Zn+2 finger

Compartment

nuclear speckle (putative)

Expression

• widely expressed
• induced by dihydrotestosterone in prostate cancer cells

More general terms

• nuclear protein
• ring finger protein

Additional terms

• protein inhibitor of activated STAT (PIAS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10401
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10401
• OMIM: https://mirror.omim.org/entry/605987
• UniProt: http://www.uniprot.org/uniprot/Q9Y6X2.html