pleckstrin homology-like domain family A member 1; apoptosis-associated nuclear protein; proline- & glutamine-rich protein; PQ-rich protein; PQR protein; proline- & histidine-rich protein; T-cell death-associated gene 51 protein (PHLDA1, PHRIP, TDAG51)

Function

• regulation of apoptosis (putative)
  • detachment-mediated programmed cell death
  • apoptosis during neuronal development
  • regulation of anti-apoptotic effects of IGF1
• translational regulation (putative)
• interacts with RPL14, EIF3S7, PABPC4

Structure

contains 1 PH domain

Compartment

• cytoplasm
• colocalizes with intracellular vesicles
• nucleus, nucleolus

Expression

• widely expressed
• highest levels in pancreas
• induced by homocysteine & other ER stress-inducing agents
• induced by phorbolester/ionomycin, & stimulation of the T-cell receptor complex in T-cells

Pathology

• strongly expressed by benign melanocytic nevi, & progressively diminished expressed in primary & metastatic melanomas

More general terms

• pleckstrin homology-like domain family A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22822
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22822
• OMIM: https://mirror.omim.org/entry/605335
• UniProt: http://www.uniprot.org/uniprot/Q8WV24.html