polyadenylate-binding protein 4; poly(A)-binding protein 4; PABP 4; inducible poly(A)-binding protein; iPABP; activated-platelet protein 1; APP-1 (PABPC4, APP1, PABP4)

Function

• binds the poly(A) tail of mRNA. may be involved in cytoplasmic regulatory processes of mRNA metabolism
• can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo
• interacts with NFX1

Structure

• Arg-518 is dimethylated, probably to asymmetric dimethylarginine
• belongs to the polyadenylate-binding protein type-1 family
• contains 1 PABC domain
• contains 4 RRM domain (RNA recognition motif)s

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed at low levels in resting normal T cells
• following T-cell activation, however, mRNA levels are rapidly up-regulated

More general terms

• polyadenylate binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q13310.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8761
• OMIM: https://mirror.omim.org/entry/603407