receptor-interacting serine/threonine protein kinase 3; RIP-like protein kinase 3; receptor-interacting protein 3; RIP-3 (RIPK3, RIP3)
Jump to navigation
Jump to search
Function
- essential for cellular necrosis in response to TNF-alpha family of death-inducing cytokines
- upon induction of necrosis, RIPK3 interacts with, & phosphorylates RIPK1 to form a necrosis-inducing complex
- RIPK3 binds to & enhances the activity of three metabolic enzymes: GLUL, GLUD1, & PYGL which may eventually stimulate the tricarboxylic acid cycle & oxidative phosphorylation, resulting in enhanced ROS production (putative)
- RIPK1 & RIPK3 undergo reciprocal autophosphorylation & trans-phosphorylation
- phosphorylation of Ser-199 plays a role in the necrosis function of RIPK3
- interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif);
- interaction induces RIPK1 phosphorylation & formation of a RIPK1-RIPK3 necrosis-inducing complex
- binds TRAF2 & is recruited to the TNFR-1 signaling complex
- interacts with PYGL, GLUL & GLUD1 & activates them
Structure
- belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family
- contains 1 protein kinase domain
Compartment
Alternative splicing
named isoforms=3
Expression
Pathology
- isoform 3 is significantly increased in colorectal carcinoma & lung carcinoma