glutamate dehydrogenase 1 (GDH1, GLUD1)
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Function
- may be involved in learning & memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (putative)
- subject to allosteric regulation
- activated by ADP
- inhibited by GTP & ATP
- ADP can occupy the NADH binding site & activate the enzyme
L-glutamate + H2O + NAD+/NADP+
<-->
2-oxoglutarate + NH3 + NADH/NADPH
Structure
- homohexamer
- belongs to the Glu/Leu/Phe/Val dehydrogenases family
Compartment
mitochondria matrix
Pathology
- defects in GLUD1 are the cause of hyperinsulinism-hyperammonemia syndrome
More general terms
References
- ↑ Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 502
- ↑ Principles of Biochemistry 6th ed., White, Handler, Smith, Hill, & Lehman (eds.) McGraw-Hill, NY 1978, pg 695
- ↑ UniProt http://www.uniprot.org/uniprot/P00367.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=GLUD1
- ↑ Wikipedia; Note: Glutamate dehydrogenase 1 entry http://en.wikipedia.org/wiki/Glutamate_dehydrogenase_1