interleukin-17 receptor D; IL-17 receptor D; IL-17RD; IL17Rhom; interleukin-17 receptor-like protein; Sef homolog; hSef (IL17RD, IL17RLM, SEF, UNQ6115/PRO20026)

Function

• feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling & ERK activation
• inihibition of FGF-induced FGFR1 tyrosine phosphorylation (putative)
• regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK
• JNK activation
• apoptosis (putative)
• interacts with MAP3K7, FGFR1, FGFR2, phosphorylated MAP2K1 or MAP2K2

Compartment

• associated with the Golgi apparatus, partially translocated to the plasma membrane upon stimulation

Alternative splicing

named isoforms=4

Expression

• expressed in highly vascularized tissues, kidney, colon, skeletal muscle, heart, small intestine
• expressed in ductal epithelial cells of salivary glands, seminal vesicles, collecting tubules of the kidney.
• isoform 1 is expressed in fetal & adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes, ovary, aortic endothelial cells, adrenal medulla > adrenal cortex.
• isoform 4 is expressed in pituitary, fetal brain, umbilical vein endothelial cells.

More general terms

• interleukin-17 receptor (IL17R)

Database

• OMIM: https://mirror.omim.org/entry/606807
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5475
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54756
• UniProt: http://www.uniprot.org/uniprot/Q8NFM7.html