mitogen activated protein kinase kinase 2 (MAP2K2, MAPK/ERK kinase 2, MEK2, dual-specificity mitogen-activated protein kinase kinase-2, PRKMK2, MKK2)

Function

• MAP2K1 & MAP2K2 activate ERK1 & ERK2
• catalyzes the concomitant phosphorylation of Thr & Tyr in a Thr-glu-Tyr sequence located in MAP kinases
• activates the ERK1 & ERK2 MAP kinases (putative)
• interacts with MORG1 (putative)
• MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1)

ATP + a protein <--> ADP + a phosphoprotein

Structure

• belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
• contains 1 protein kinase domain

Pathology

• defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome

More general terms

• MAP2K/MEK

Database

• UniProt: http://www.uniprot.org/uniprot/P36507.html
• OMIM: https://mirror.omim.org/entry/115150
• OMIM: https://mirror.omim.org/entry/601263
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5605