mitogen-activated protein kinase organizer 1; WD repeat domain-containing protein 83; MAPK organizer 1 (WDR83, MORG1)

Function

• molecular scaffold protein
  • assembly of a multicomponent scaffold for the ERK pathway
• enhances ERK activation at low levels, inhibits at high levels
• response to hypoxia
  • negative regulation of HIF1A via EGLN3
  • degradation of HIF1A
• may act by recruiting signaling complexes to a specific upstream activator
• may also be involved in pre-mRNA splicing
• interacts with EGLN3, MAP2K1, MAP2K2, MAP2K1IP1, ARAF, MAPK1, MAPK3
• identified in the spliceosome C complex

Structure

• belongs to the WD repeat MORG1 family
• contains 7 WD repeats

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic, partially nuclear (putative)

More general terms

• scaffold protein

Component of

• spliceosome C complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BRX9.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84292
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84292
• UniProt: http://www.uniprot.org/uniprot/Q9BRX9.html